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KMID : 0378119910180020561
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Chungnam Medical Journal
1991 Volume.18 No. 2 p.561 ~ p.570
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The Effect of Midazolam and Diazepam on Increased Blood Pressure Heart Rate and Intraocular Pressure by Ketamine
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Abstract
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The effect of midazolam and diazepam on increased blood pressure, heart rate and intraocular pressure by ketamine were evaluated in thirty patients.
All patients were devided into three groups as follow；
Group 1 (n= 10)： Ketamine 2mg/kg was administered intravenously before endotracheal intubation(control).
Group 2 (n= 10)： Midazolam 0.15mg/kg was administered intravenously three munutes before ketamine administration.
Group 3 (n= 10)： Diazepam 0.3mg/kg was administered intravenously three minutes before ketamine administration.
The changes of systolic and diastolic blood pressure, heart rate and intraocular pressure were measured following drug administration and endotracheal intubation in all groups. Succinylcholine 1mg/kg was administered intravenously for endotracheal intubation.
The results were as follows；
1) Increased systolic and diastolic blood pressure, heart rate and intraocular pressure due to ketamine(2mg/kg) i.v. administration were prevented with midazolam(0.15mg,/kg) or diazepam(0.3mg/kg) i.v. pretreatement effectively.
2) Anterograde amnesia effect was good enough in midazolam and diazepam i.v. pretreatment groups.
3) There was no pain with midazolam i.v. administration and showed good tranquilizing effect. From the above result, midazolam i.v. pretreatment is recommended to offset of increased cardiovascular effects and increased intraocular pressure due to ketamine administration.
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